I have found that a good chunk of random opensource projects won't run on the zero 2. The ARM core is ARM7 and doesn't support modern instructions, so plenty of software just immediately dies with 'Illefal Instruction'.

Also, it's 32 bit, and a lot of software is starting to depend on the massive address spaces offered by 64 bit.

And there is no high ram model. Some stuff just gobbles so much ram that 512M isn't practical.