Vernor Vinge does a great job with this in A Fire Upon the Deep and A Deepness in the Sky. I do wish that he had written more about Pham Numen and the Qeng Ho, back in their Slow Zone heyday.
Alastair Reynolds also does a great job with this in his Revelation Space trilogy, with his lighthuggers.
One started with him hiding in a nursing home, after faking his death. I don't recall specifics, but I suppose that it's possible that all of the other characters are his descendants. And they had spent a long time looking for him.
In the other, he'd been resurrected by some godlike AI as a meatspace agent. Millennia after the Qeng Ho era, I think.
Alastair Reynolds also does a great job with this in his Revelation Space trilogy, with his lighthuggers.