That's not really an indictment of the scientific method though. So isolated lycopene isn't as good as eating a tomato. Surely there are scientists that are iterating on that, trying to find the combination of compounds that does give the desired outcome, right?
That wasn't a critique on science, just noting that the simplest approach (trying to pin down health benefits to a single substance) doesn't work well in this case. It's a good idea to start with the simplest hypothesis; if that is rejected you move to more complex ones. In that case multiple substances are probably acting non-independently in our physiology, thus your experiments need to accommodate that.
