Hacker Newsnew | past | comments | ask | show | jobs | submit | Rebellos's commentslogin

Not denying that acetaminophen/paracetamol has a horrible therapeutic index, but there are reasons why it is still so widely used. Despite potential hepatoxicity, it is considered the safest pain relief drug (this emerging research notwithstanding)

Ibuprofen is not better in every way. For instance ibuprofen, as well as other NSAIDs, is much less gentle on gastrointestinal tract and puts much more strain on kidneys.

Some people (e.g. with inflammatory bowel diseases or renal diseases) do not tolerate NSAIDs well, which is why acetaminophen is on the same step of analgesic ladder - it is still considered better in some cases. Both are also used complementary to each other in pediatrics.


Your comment is fair; obviously I wrote a pretty flippant comment, but the message is largely useful for most people.

The fact is that (largely due to the incredible marketing of Johnson & Johnson's Tylenol brand in the US) way too many people think acetaminophen is "safe and effective" when it's actually both pretty unsafe and pretty ineffective. Most people just "pop a Tylenol" by default without realizing it's not much better than placebo.

Sure there are cases where people have unique risks and should avoid NSAIDs. But for the vast majority of the public, if they or their kid are dealing with a headache, fever, menstrual cramp, or other transient pain or fever, they should reach for ibuprofen (with a snack) over acetaminophen. It's not remotely a close call.

I'm frankly pleased that people are becoming more aware of this and I don't mind taking a couple correction comments for presenting the info in a superficial way.


NSAIDs can cause GI issues if taken with or without a snack.

They reduce production of the stomach’s protective mucous lining. Snacks don’t help with that.

They can also cause kidney damage.

Occasional use for an otherwise healthy person is fine. But Tylenol as long as you are careful not to take too much is generally safer.


Great paper! Sorry to nitpick, because your approach is right, but one important detail is wrong - you are not reading what NIH said, but simply a paper made by someone that NIH provides access to. It is important to remember that things on pubmed can be wrong, or subjective and biased.

See header "As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health.", and you can click on "Author information" to learn more about the authors.


Amazing little game, thank you!

Being able to swipe over the equation instead of tapping would improve playability a lot! Also I sometimes feel like the first tap is not registered right after the new MN appears.


Thanks :D

Will add swipe controls to my todos, I decided against adding it because the other word search games on the site will occasionally overflow off-screen (so swiping is required to move around the grid) but might add it as a toggle for this game.

Will look into the tap problem, thanks for reporting!


Follow-up on this feedback - it would be nice if the UI supported tapping individual blocks sequentially like the game strands does. Currently (on safari on iOS at least) if you go to highlight e.g. 6+4 one at a time the UI reports “invalid equation” if you highlight 6 and + instead of highlighting the start and end of the range in one go

Otherwise, cool game!


Ya thinking of adding this. For the moment I just made it so operators can't be highlighted at all, making it more clear that it's the numbers that need to be tapped (since equations can't start or end with an operator)


G f 223


ECC memory controller performs memory scrubbing periodically, in the background, during which it checks parity and corrects any bitflips. Otherwise ECC would not work nearly as well as it does.


Parity isn't checked during every single row refresh?


AFAIK, row refresh is done within each memory chip, while the ECC bits are normally on a separate chip (for instance, where a non-ECC module has 8 chips, an ECC modules has 9 chips), so ECC scrubbing has to be done in the memory controller.


CPU by common sense should be Turing complete.


Not necessarily. It depends on the installation and does, usually, contain 2 tones. For instance - https://en.wikipedia.org/wiki/Precise_Tone_Plan - none of two frequencies used in NA's dialtone is E.


Ah well it always worked for me... may have been a case of "close enough for rock'n roll" though.


Guidelines | FAQ | Lists | API | Security | Legal | Apply to YC | Contact

Search: